Annonaceous acetogenin bullatacin cytotoxic against multidrug-resistant human mammary adenocarcinoma cells

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Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison and Jerry L. McLaughlinCorresponding Author Contact Information, E-mail The Corresponding Author

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333, USA
Received 19 December 1996;
Revised 14 January 1997;
accepted 14 January 1997.
Available online 15 December 1997.

Abstract

Cytotoxic effects of the previous termAnnonaceous acetogenin,next term bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the previous termAnnonaceous acetogenins,next term and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.
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